We are employing the transgenic and/or knockout mice to study the mechanism of cardiovascular diseases, such as myocardial infarction (MI) and hypertrophy cardiomyopathy (HCM). We have the focus on the field of non-coding RNAs specifically, including miRNAs, lncRNAs, circRNAs, and among others. We are expecting to illuminate the underlying mechanism and developing novel targets of cardiovascular gene therapy