Pluripotent stem cells (PSCs) include embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs), yet the mechanisms of PSCs and directed differentiation into cardiovascular cells (cardiomyocytes and endothelial cells) remain poorly investigated. We are studying cardiovascular differentiation/development in human PSCs to define the underlying epigenetic molecular events that enable get more differentiated and mature cardiovascular cells for translational applications.