EN

科研成果


2017

Xie Y, Wang D, Lan F, Wei G, Ni T, Chai R, Liu D, Hu S, Li M, Li D, Wang H, Wang Y. An episomal vector-based CRISPR/Cas9 system for highly efficient gene knockout in human pluripotent stem cells. Sci Rep. 2017; 7(1):2320.

Liu Q, Lyu Z, Yu Y, Zhao ZA, Hu S, Yuan L, Chen G, Chen H. Synthetic Glycopolymers for Highly Efficient Differentiation of Embryonic Stem Cells into Neurons: Lipo- or Not? ACS Appl Mater Interfaces. 2017; 9(13):11518-11527.


2017年以前

Liang P, Sallam K, Wu H, Li Y, Itzhaki I, Garg P, Zhang Y, Vermglinchan V, Lan F, Gu M, Gong T, Zhuge Y, He C, Ebert AD, Sanchez-Freire V, Churko J, Hu S, Sharma A, Lam CK, Scheinman MM, Bers DM, Wu JC. Patient-Specific and Genome-Edited Induced Pluripotent Stem Cell-Derived Cardiomyocytes Elucidate Single-Cell Phenotype of Brugada Syndrome. J Am Coll Cardiol. 2016; 68(19):2086-2096.

Hu S*, Zhao MT, Jahanbani F, Shao NY, Lee WH, Chen H, Snyder MP, Wu JC. Effects of cellular origin on differentiation of human induced pluripotent stem cell-derived endothelial cells. JCI Insight. 2016; 1(8):e85558.

胡士军*, 虞游, 方星, 雷伟, 赵振奥. 诱导多能干细胞与心脏再生. 上海大学学报. 2016; 22(3):285.

Shen H#, Wang Y#, Zhang Z, Yang J, Hu S*, Shen Z*. Mesenchymal stem cells for cardiac regenerative therapy: optimization of cell differentiation strategy. Stem Cells Int. 2015; 2015:524756.

Noman MZ, Janji B, Hu S, Wu JC, Martelli F, Bronte V, Chouaib S*. Tumor promoting effects of myeloid derived suppressor cells are potentiated by hypoxia-induced expression of miR-210. Cancer Res. 2015; 75(18):3771-87.

Lee WH#, Nguyen P#, Hu S, Liang G, Ong SG, Han L, Sanchez-Freire V, Lee AS, Vasanawala M, Segall G, Wu JC*. Variable activation of the DNA damage response pathways in patients undergoing single-photon emission computed tomography myocardial perfusion imaging. Circ Cardiovasc Imaging. 2015; 8(2):e002851.

Gu M#, Mordwinkin NM#, Kooreman NG, Lee J, Wu H, Hu S, Churko JM, Diecke S, Burridge PW, He C, Barron FE, Ong SG, Gold JD, Wu JC*. Pravastatin reverses obesity-induced dysfunction of induced pluripotent stem cell-derived endothelial cells via a nitric oxide-dependent mechanism. Eur Heart J. 2015; 36(13):806-16.

Nguyen PK#, Lee WH#, Li YF#, Hong WX, Hu S, Chan C, Liang G, Nguyen I, Ong SG, Churko J, Wang J, Altman RB, Fleischmann D, Wu JC*. Assessment of the Radiation Effects of Cardiac CT Angiography Using Protein and Genetic Biomarkers. JACC Cardiovasc Imaging. 2015; 8(8):873-84.

Wang Y#, Liang P#, Lan F#, Wu H#, Lisowski L, Gu M, Hu S, Kay MA, Urnov FD, Shinnawi R, Gold JD, Gepstein L, Wu JC*. Genome Editing of Isogenic Human Induced Pluripotent Stem Cells Recapitulates Long QT Phenotype for Drug Testing. J Am Coll Cardiol. 2014; 64(5):451-9.

Sanchez-Freire V, Lee AS, Hu S, Abilez OJ, Liang P, Lan F, Huber BC, Ong SG, Hong WX, Huang M, Wu JC*. Effect of human donor cell source on differentiation and function of cardiac induced pluripotent stem cells. J Am Coll Cardiol. 2014; 64(5):436-48.

de Almeida PE#, Meyer EH#, Kooreman NG#, Diecke S, Dey D, Sanchez-Freire V, Hu S, Ebert A, Odegaard J, Mordwinkin N, Brouwer TP, Lo D, Montoro D, Longaker MT, Negrin RS, Wu JC*. Transplanted terminally differentiated induced pluripotent stem cells are accepted by immune mechanisms similar to self-tolerance. Nat Commun. 2014; 5:3903.

Zhu H, Hu S, Baker J*. JMJD5 regulates cell cycle and pluripotency in human embryonic stem cells. Stem Cells. 2014; 32(8):2098-110.

Hu S, Wilson KD, Ghosh Z, Han L, Wang Y, Lan F, Ransohoff KJ, Wu JC*. MicroRNA-302 increases reprogramming efficiency via repression of NR2F2. Stem Cells. 2013; 31(2):259-68.

Lister R#, Mukanel EA#, Nery JR, Urich M, Puddifoot CA, Johnson ND, Lucero J, Huang Y, Dwork AJ, Schultz MD, Yu M, Tonti-Filippini J, Pastor WA, Heyn H, Hu S, Wu JC, Rao A, Eateller M, He C, Haghighi GF, Sejnowski TJ, Behrens MM*, Ecker JR*. Global epigenomic reconfiguration during mammalian brain development. Science. 2013; 341(6146):1237905.

Huber BC#, Ransohoff JD#, Ransohoff KJ, Riegler J, Ebert A, Kodo K, Gong Y, Sanchez-Freire V, Dey D, Kooreman NG, Diecke S, Zhang WY, Odegaard J, Hu S, Gold JD, Robbins RC, Wu JC*. Costimulation-Adhesion Blockade is Superior to Cyclosporine A and Prednisone Immunosuppressive Therapy for Preventing Rejection of Differentiated Human Embryonic Stem Cells Following Transplantation. Stem Cells. 2013; 31(11):2354-63.

Lan F#, Lee AS#, Liang P#, Sanchez-Freire V, Nguyen PK, Wang L, Han L, Yen M, Wang Y, Sun N, Abilez OJ, Hu S, Ebert AD, Navarrete EG, Simmons CS, Wheeler M, Pruitt B, Lewis R, Yamaguchi Y, Ashley EA, Bers DM, Robbins RC, Longaker MT, Wu JC*. Abnormal calcium handling properties underlie familial hypertrophic cardiomyopathy pathology in patient-specific induced pluripotent stem cells. Cell Stem Cell. 2013; 12(1):101-13.

Su W#, Wang L#, Zhou M, Liu Z, Hu S, Tong L, Liu Y, Fan Y, Kong D, Zheng Y, Han Z, Wu JC, Xiang R*, Li Z*. Human embryonic stem cell-derived endothelial cells as cellular delivery vehicles for treatment of metastatic breast cancer. Cell Transplant. 2013; 22(11):2079-90.

Daadi MM, Hu S, Klausner J, Li Z, Sofilos M, Sun G, Wu JC, Steinberg GK*. Imaging neural stem cell graft-induced structural repair in stroke. Cell Transplant. 2013; 22(5):881-92.

Wang Y#, Zhang WY#, Hu S, Lan F, Lee AS, Huber B, Lisowski L, Liang P, Huang M, de Almeida PE, Won JH, Sun N, Robbins RC, Kay MA, Urnov FD, Wu JC*. Genome editing of human embryonic stem cells and induced pluripotent stem cells with zinc finger nuclease for cellular imaging. Circ Res. 2012; 111(12):1494-503.

Gu M#, Nguyen PK#, Lee AS, Xu D, Hu S, Plews J, Han L, Huber BC, Lee WH, Gong Y, de Almeida PE, Lyons J, Ikeno F, Pacharinsak C, Connolly AJ, Gambhir SS, Robbins RC, Longaker MT*, Wu JC*. Microfluidic single-cell analysis shows that porcine induced pluripotent stem cell-derived endothelial cells improve myocardial function by paracrine activation. Circ Res. 2012; 111(7):882-93.

Lan F#, Liu J#, Narsinh KH#, Hu S, Han L, Lee AS, Karow M, Nguyen PK, Nag D, Calos MP, Robbins RC, Wu JC*. Safe genetic modification of cardiac stem cells using a site-specific integration technique Circulation. 2012; 126(11):S20-8.

Liu J#, Narsinh KH#, Lan F#, Wang L, Nguyen PK, Hu S, Lee A, Han L, Gong Y, Huang M, Nag D, Rosenberg J, Chouldechova A, Robbins RC, Wu JC*. Early stem cell engraftment predicts late cardiac functional recovery: pre-clinical insights from molecular imaging. Circ Cardiovasc Imaging. 2012; 5(4):481-90.

Levi B#, Hyun JS#, Montoro DT#, Lo DD, Chan CK, Hu S, Sun N, Lee M, Grova M, Connolly AJ, Wu JC, Gurtner GC, Weissman IL, Wan DC, Longaker MT*. In vivo directed differentiation of pluripotent stem cells for skeletal regeneration. Proc Natl Acad Sci U S A. 2012; 109(50):20379-84.

Sun N#, Yazawa M#, Liu J, Han L, Sanchez-Freire V, Abilez OJ, Navarrete EG, Hu S, Wang L, Lee A, Pavlovic A, Lin S, Chen R, Hajjar RJ, Snyder MP, Dolmetsch RE, Butte MJ, Ashley EA, Longaker MT, Robbins RC, Wu JC*. Patient-specific induced pluripotent stem cells as a model for familial dilated cardiomyopathy. Sci Transl Med. 2012; 4(130):130ra47.

Reddy S, Zhao M, Hu DQ, Fajardo GA, Hu S, Ghosh Z, Rajagopalan V, Wu JC, Bernstein D*. Dynamic microrna expression during the transition from right ventricular hypertrophy to failure. Physiol Genomics. 2012; 44(10):562-75.

Levi B, Nelson ER, Hyun JS, Glotzbach JP, Li S, Nauta A, Montoro DT, Lee M, Commons GC, Hu S, Wu JC, Gurtner GC, Longaker MT*. Enhancement of human adipose-derived stromal cell angiogenesis through knockdown of a BMP-2 inhibitor. Plast Reconstr Surg. 2012; 129(1):53-66.

Hu S, Huang M, Nguyen PK, Gong Y, Li Z, Jia F, Lan F, Liu J, Nag D, Robbins RC and Wu JC*. Novel MicroRNA cocktail for improving survival and function of cardiac progenitor cell transplantation. Circulation. 2011; 124(11):S27-34.

Huang M, Nguyen P, Jia F, Hu S, Gong Y, de Almeida PE, Wang L, Nag D, Kay MA, Giaccia AJ, Robbins RC, Wu JC*. Double knockdown of prolyl hydroxylase and factor-inhibiting hypoxia-inducible factor with nonviralminicircle gene therapy enhances stem cell mobilization and angiogenesis after myocardial infarction. Circulation. 2011; 124(11):S46-54.

Lee AS#, Xu D#, Nguyen PK, Nag D, Lyons JK, Han L, Hu S, Lan F, Huang M, Liu J, Narsinh KN, Long CT, de Almeida P, Levi B, Kooreman N, Bangs C, Pacharinsak C, Yeung AC, Gambhir SS, Longaker MT*, Wu JC*. Preclinical derivation and imaging of autologously transplanted canine induced pluripotent stem cells. J Biol Chem. 2011; 286(37):32697-704.

Ghosh Z#, Huang M#, Hu S#, Wilson KD, Dey D, Wu JC*. Dissecting the oncogenic and tumorigenic potential of differentiated human induced pluripotent stem cells and human embryonic stem cells. Cancer Res. 2011; 71(14):5030-9.

Levi B, James AW, Nelson ER, Hu S, Sun N, Peng M, Wu J, Longaker MT*. Studies in adipose-derived stromal cells: migration and participation in repair of cranial injury after systemic injection. Plast Reconstr Surg. 2011; 127(3):1130-40.

Narsinh KH, Sun N, Sanchez-Freire V, Lee AS, Almeida P, Hu S, Jan T, Wilson KD, Leong D, Rosenberg J, Yao M, Robbins RC, Wu JC*. Single cell transcriptional profiling reveals heterogeneity of human induced pluripotent stem cells. J Clin Invest. 2011; 121(3):1217-21.

Li Z#, Hu S#, Ghosh Z, Han Z, Wu JC*. Functional characterization and expression profiling of human induced pluripotent stem cell- and embryonic stem cell-derived endothelial cells. Stem Cells Dev. 2011; 20(10):1701-10.

Hu S, Huang M, Li Z, Jia F, Ghosh Z, Lijkwa MA, Fasanaro P, Sun N, Wang X, Martelli F, Robbins RC, Wu JC*. MicroRNA-210 as a novel therapy for treatment of ischemic heart disease. Circulation. 2010; 122(11):S124-31.

Wilson KD, Hu S, Venkatasubrahmanyam S, Fu JD, Sun N, Abilez OJ, Baugh JJ, Jia F, Ghosh Z, Li RA, Butte AJ, Wu JC*. Dynamic microRNA expression programs during cardiac differentiation of human embryonic stem cells: role for miR-499. Circ Cardiovasc Genet. 2010; 3(5):426-35.

Ghosh Z, Wilson KD, Wu Y, Hu S, Quertermous T, Wu JC*. Persistent donor cell gene expression among human induced pluripotent stem cells contributes to differences with human embryonic stem cells. PLoS One. 2010; 5(2):e8975.

Su RW, Lei W, Liu JL, Zhang ZR, Jia B, Feng XH, Ren G, Hu SJ, Yang ZM*. The integrative analysis of microRNA and mRNA expression in mouse uterus under delayed implantation and activation. PLoS One. 2010; 5(11):e15513.

Sun N, Panetta NJ, Gupta DM, Wilson KD, Lee A, Jia F, Hu S, Cherry AM, Robbins RC, Longaker MT, Wu JC*. Feeder-free derivation of induced pluripotent stem cells from adult human adipose stem cells. Proc Natl Acad Sci U S A. 2009; 106(37):15720-5.

Huang M, Chen Z, Hu S, Jia F, Li Z, Hoyt G, Robbins RC, Kay MA, Wu JC*. Novel minicircle vector for gene therapy in murine myocardial infarction. Circulation. 2009; 120(11):S230-7.

Hu SJ, Ren G, Liu JL, Zhao ZA, Yu YS, Su RW, Ma XH, Ni H, Lei W, Yang ZM*. MicroRNA expression and regulation in mouse uterus during embryo implantation. J Biol Chem. 2008; 283(34):23473-84.

Gao F, Lei W, Diao HL, Hu SJ, Luan LM, Yang ZM*. Differential expression and regulation of prostaglandin transporter and metabolic enzymes in mouse uterus during blastocyst implantation. Fertil Steril. 2007; 88(4): S1256-65.

Ma XH, Hu SJ, Ni H, Zhao YC, Tian Z, Liu JL, Ren G, Liang XH, Yu H, Wan P, Yang ZM*. Serial analysis of gene expression in mouse uterus at the implantation site. J Biol Chem. 2006; 281 (14):9351-60.

Ma XH, Hu SJ, Yu H, Xu LB, Yang ZM*. Differential expression of transcriptional repressor snail gene at implantation site in mouse uterus. Mol Reprod Dev. 2006; 73(2):133-41.

Chen Y, Ni H, Ma XH, Hu SJ, Luan LM, Ren G, Zhao YC, Li SJ, Diao HL, Xu X, Zhao ZA, Yang ZM*. Global analysis of differential luminal epithelial gene expression at mouse implantation sites. J Mol Endocrinol. 2006; 37(1):147-61.


# 代表为第一作者

* 代表为通讯作者