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雷伟


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       雷伟博士,苏州大学心血管病研究所副教授,2010年毕业于东北农业大学组织胚胎学专业,获得博士学位。2011年到美国范德堡大学(Vanderbilt University)做博士后研究,从事胚胎早期发育方面的研究。在J Biol Chem、Endocrinology和PLoS ONE等杂志上发表科研论文17篇。雷伟博士于2015年3月加入苏州大学心血管病研究所,开展胚胎干细胞干性维持和向心血管细胞定向分化的相关机制研究。


教育与工作经历:

2015 - 至今		苏州大学			副教授
2011 - 2015		美国范德堡大学		博士后研究员
2005 - 2010		东北农业大学		博士
2001 - 2005		东北农业大学		学士

科研成果:

[研究论文]

Lei W, Ni H, Herington J, Reese J, Paria BC. Alkaline Phosphatase Protects Lipopolysaccharide-Induced Early Pregnancy Defects in Mice. PLoS One. 2015; 10(4):e0123243.

Lei W, Herington J, Galindo CL, Ding TB, Brown N, Reese J, Paria BC. Cross-species transcriptomic approach reveals genes relating to hamster implantation sites. Reproduction. 2014;148(6):607-21.

Lei W, Nguyen H, Brown N, Ni H, Kiffer-Moreira T, Reese J, Millan JL, Paria BC. Alkaline phosphatases contribute to uterine receptivity, implantation, decidualization and defense against bacterial endotoxin in hamsters. Reproduction. 2013; 146(5):419-32.

Lei W, Feng XH, Deng WB, Ni H, Zhang ZR, Jia B, Yang XL, Wang TS, Liu JL, Su RW, Liang XH, Qi QR, Yang ZM. Progesterone and DNA damage encourage uterine cell proliferation and decidualization through up-regulating ribonucleotide reductase 2 expression during early pregnancy in mice. J Biol Chem. 2012; 287(19):15174-92.

Su RW#, Lei W#, Liu JL, Zhang ZR, Jia B, Feng XH, Gang Ren, Hu SJ and Yang ZM. The integrative analysis of microRNA and mRNA expression in mouse uterus under delayed implantation and activation. PLoS One. 2010; 5(11):e15513. (# 共同第一作者)

Zuo RJ, Zhao YC, Lei W, Wang TS, Wang BC, Yang ZM. Crystallin αB acts as a molecular guard in mouse decidualization: Regulation and function during early pregnancy. FEBS Lett. 2014; 588(17):2944-51.

Liang X, Zhang XH, Han BC, Lei W, Qi QR, Wang TS, Gu XW, Yang ZM. Progesterone and heparin-binding epidermal growth factor-like growth factor regulate the expression of tight junction protein Claudin-3 during early pregnancy. Fertil Steril. 2013; 100(5):1410-8.

Zhang XH, Tian Z, Lei W, Zhao ZA, Wang TS, Yang ZM. Differential expression of interleukin 1 receptor type II during mouse decidualization. Reprod Sci. 2012; 19(9):923-31.

Su RW, Jia B, Ni H, Lei W, Yue SL, Feng XH, Deng WB, Liu JL, Zhao ZA, Wang TS, Yang ZM. Junctional adhesion molecule 2 mediates the interaction between hatched blastocyst and luminal epithelium: induction by progesterone and LIF. PLoS One. 2012; 7(4):e34325.

Liu JL, Liang XH, Su RW, Lei W, Jia B, Feng XH, Li ZX, Yang ZM. Combined analysis of microRNome and 3'-UTRome reveals a species-specific regulation of progesterone receptor expression in the endometrium of rhesus monkey. J Biol Chem. 2012; 287(17):13899-910.

Sha AG, Liu JL, Jiang XM, Ren JZ, Ma CH, Lei W, Su RW, Yang ZM. Genome-wide identification of micro-ribonucleic acids associated with human endometrial receptivity in natural and stimulated cycles by deep sequencing. Fertil Steril. 2011; 96(1):150-155.e5.

Liang XH, Zhao ZA, Deng WB, Lei W, Xu X, Zhang XH, Su RW, and Yang ZM. Estrogen regulates amiloride-binding protein 1 through CCAAT/enhancer-binding protein-beta in mouse uterus during embryo implantation and decidualization. Endocrinology. 2010; 151(10):5007-16.

Ni H, Yu XJ, Liu HJ, Lei W, Rengaraj D, Li XJ and Yang ZM. Progesterone regulation of glutathione S-transferase Mu2 expression in mouse uterine luminal epithelium during preimplantation period. Fertil Steril. 2009; 91(5):S2123-30.

Diao HL, Su RW, Tan HN, Li SJ, Lei W, Deng WB and Yang ZM. Effects of androgen on embryo implantation in the mouse delayed-implantation model. Fertil Steril. 2008; 90(4:S1376-83.

Hu SJ, Ren G, Liu JL, Zhao ZA, Yu YS, Su RW, Ma XH, Ni H, Lei W and Yang ZM. MicroRNA expression and regulation in mouse uterus during embryo implantation. J Biol Chem. 2008; 283(34):23473-84.

Gao F, Lei W, Diao HL, Hu SJ, Luan LM and Yang ZM. Differential expression and regulation of prostaglandin transporter and metabolic enzymes in mouse uterus during blastocyst implantation. Fertil Steril. 2007; 88(4):S1256-65.

雷伟, 杨增明. 胚胎着床的分子调控网络. 生理科学进展. 2010; 41(6):417-22.


科研项目:
2015 - 2019		苏州大学人才引进启动项目基金
2015 - 2017		江苏省高校自然科学研究面上项目
2015 - 2018		苏州市科技计划应用基础研究项目